PRECLINICAL SAFETY AND EFFICACY OF 24R,25-DIHYDROXYVITAMIN D3 OR LACTOSYLCERAMIDE TREATMENT TO ENHANCE FRACTURE REPAIR

Preclinical safety and efficacy of 24R,25-dihydroxyvitamin D3 or lactosylceramide treatment to enhance fracture repair

Background/Objective: Cyp24a1-null mice deficient in 24,25(OH)2D3 display impaired callus formation during the endochondral phase of bone fracture repair.The 24,25(OH)2D3 metabolite acted by binding to the TLC domain containing 3B isoform 2 (TLCD3B2, previously named FAM57B2) effector protein, which then synthesizes lactosylceramide (LacCer).Treatm

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Cold Sore, Cold Soul? An Examination of Orolabial Herpes in Film

The sociocultural phenomenon of herpes is attributed to two strains of the herpes simplex virus: herpes simplex virus Napkin Holders type 1 (HSV-1) causes orolabial cold sores while herpes simplex virus type 2 (HSV-2) is typically identified in genital lesions, though both viruses may cause clinically similar signs and symptoms anywhere in or on th

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